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Key Regulators of Intestinal Stem Cells: Diet, Microbiota, and Microbial Metabolites by Chensi Yao; Xiaowen Gou; Chuanxi Tian; Lijuan Zhou; Rui Hao; Li Wan; Zeyu Wang; Min Li; Xiaolin Tong is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Key Regulators of Intestinal Stem Cells: Diet, Microbiota, and Microbial Metabolites about?

Interactions between diet and the intestinal microbiome play an important role in human health and disease development. It is well known that such interactions, whether direct or indirect, trigger a series of metabolic reactions in the body. Evidence suggests that intestinal stem cells (ISCs), which are phenotypic precursors of various intestinal epithelial cells, play a significant role in the regulation of intestinal barrier function and homeostasis. The advent and evolution of intestinal organoid culture techniques have presented a key opportunity to study the association between the intestinal microenvironment and ISCs. As a result, the effects exerted by dietary factors, intestinal microbiomes, and their metabolites on the metabolic regulation of ISCs and the potential mechanisms underlying such effects are being gradually revealed. This review summarises the effects of different dietary patterns on the behaviour and functioning of ISCs and focuses on the crosstalk between intestinal microbiota, related metabolites, and ISCs, with the aim of fully understanding the relationship between these three factors and providing further insights into the complex mechanisms associated wi

Who reads Key Regulators of Intestinal Stem Cells: Diet, Microbiota, and Microbial Metabolites?

Author

Chensi Yao; Xiaowen Gou; Chuanxi Tian; Lijuan Zhou; Rui Hao; Li Wan; Zeyu Wang; Min Li; Xiaolin Tong

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)