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Hemolytic Disease of the Fetus and Newborn: Systematic Literature Review of the Antenatal Landscape by Derek P. de Winter; Allysen Kaminski; May Lee Tjoa; Dick Oepkes is a Medicine article available to read on EtoBox.

What is Hemolytic Disease of the Fetus and Newborn: Systematic Literature Review of the Antenatal Landscape about?

## Abstract ## Background Prevention of pregnancy-related alloimmunization and the management of hemolytic disease of the fetus and newborn (HDFN) has significantly improved over the past decades. Considering improvements in HDFN care, the objectives of this systematic literature review were to assess the prenatal treatment landscape and outcomes of Rh(D)- and K-mediated HDFN in mothers and fetuses, to identify the burden of disease, to identify evidence gaps in the literature, and to provide recommendations for future research. ## Methods We performed a systematic search on MEDLINE, EMBASE and clinicaltrials.gov. Observational studies, trials, modelling studies, systematic reviews of cohort studies, and case reports and series of women and/or their fetus with HDFN caused by Rhesus (Rh)D or Kell alloimmunization. Extracted data included prevalence; treatment patterns; clinical outcomes; treatment efficacy; and mortality. ## Results We identified 2,541 articles. After excluding 2,482 articles and adding 1 article from screening systematic reviews, 60 articles were selected. Most abstracted data were from case reports and case series. Prevalence was 0.047% and 0.006% for Rh(D)- and K

Who reads Hemolytic Disease of the Fetus and Newborn: Systematic Literature Review of the Antenatal Landscape?

Author

Derek P. de Winter; Allysen Kaminski; May Lee Tjoa; Dick Oepkes

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)