Skip to content

Opening book details…

Can I read Temporal Control of the Integrated Stress Response by a Stochastic Molecular Switch on EtoBox?

Temporal Control of the Integrated Stress Response by a Stochastic Molecular Switch by Klein, Philipp (author);Kallenberger, Stefan M. (author);Roth, Hanna (author);Roth, Karsten (author);Ly-Hartig, Thi Bach Nga (author);Magg, Vera (author);Aleš, Janez (author);Talemi, Soheil Rastgou (author);Qiang, Yu (author);Wolf, Steffen (author);Oleksiuk, Olga (author);Kurilov, Roma (author);Di Ventura, Barbara (author);Bartenschlager, Ralf (author);Eils, Roland (author);Rohr, Karl (author);Hamprecht, Fred A. (author);Höfer, Thomas (author);Fackler, Oliver T. (author);Stoecklin, Georg (author);Ruggieri, Alessia (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Temporal Control of the Integrated Stress Response by a Stochastic Molecular Switch about?

Stress granules (SGs) are formed in the cytosol as an acute response to environmental cues and activation of the integrated stress response (ISR), a central signaling pathway controlling protein synthesis. Using chronic virus infection as stress model, we previously uncovered a unique temporal control of the ISR resulting in recurrent phases of SG assembly and disassembly. Here, we elucidate the molecular network generating this fluctuating stress response by integrating quantitative experiments with mathematical modeling and find that the ISR operates as a stochastic switch. Key elements controlling this switch are the cooperative activation of the stress-sensing kinase PKR, the ultrasensitive response of SG formation to the phosphorylation of the translation initiation factor eIF2α, and negative feedback via GADD34, a stress-induced subunit of protein phosphatase 1. We identify GADD34 messenger RNA levels as the molecular memory of the ISR that plays a central role in cell adaptation to acute and chronic stress.

Who reads Temporal Control of the Integrated Stress Response by a Stochastic Molecular Switch?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Klein, Philipp (author);Kallenberger, Stefan M. (author);Roth, Hanna (author);Roth, Karsten (author);Ly-Hartig, Thi Bach Nga (author);Magg, Vera (author);Aleš, Janez (author);Talemi, Soheil Rastgou (author);Qiang, Yu (author);Wolf, Steffen (author);Oleksiuk, Olga (author);Kurilov, Roma (author);Di Ventura, Barbara (author);Bartenschlager, Ralf (author);Eils, Roland (author);Rohr, Karl (author);Hamprecht, Fred A. (author);Höfer, Thomas (author);Fackler, Oliver T. (author);Stoecklin, Georg (author);Ruggieri, Alessia (author)
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Physical Sciences)

More by Klein, Philipp (author);Kallenberger, Stefan M. (author);Roth, Hanna (author);Roth, Karsten (author);Ly-Hartig, Thi Bach Nga (author);Magg, Vera (author);Aleš, Janez (author);Talemi, Soheil Rastgou (author);Qiang, Yu (author);Wolf, Steffen (author);Oleksiuk, Olga (author);Kurilov, Roma (author);Di Ventura, Barbara (author);Bartenschlager, Ralf (author);Eils, Roland (author);Rohr, Karl (author);Hamprecht, Fred A. (author);Höfer, Thomas (author);Fackler, Oliver T. (author);Stoecklin, Georg (author);Ruggieri, Alessia (author)

Browse all works by Klein, Philipp (author);Kallenberger, Stefan M. (author);Roth, Hanna (author);Roth, Karsten (author);Ly-Hartig, Thi Bach Nga (author);Magg, Vera (author);Aleš, Janez (author);Talemi, Soheil Rastgou (author);Qiang, Yu (author);Wolf, Steffen (author);Oleksiuk, Olga (author);Kurilov, Roma (author);Di Ventura, Barbara (author);Bartenschlager, Ralf (author);Eils, Roland (author);Rohr, Karl (author);Hamprecht, Fred A. (author);Höfer, Thomas (author);Fackler, Oliver T. (author);Stoecklin, Georg (author);Ruggieri, Alessia (author)