Can I read Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study on EtoBox?

Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study by Kohler, Philipp (author);Güsewell, Sabine (author);Seneghini, Marco (author);Egger, Thomas (author);Leal, Onicio (author);Brucher, Angela (author);Lemmenmeier, Eva (author);Möller, J. Carsten (author);Rieder, Philip (author);Ruetti, Markus (author);Stocker, Reto (author);Vuichard-Gysin, Danielle (author);Wiggli, Benedikt (author);Besold, Ulrike (author);Kuster, Stefan P. (author);McGeer, Allison (author);Risch, Lorenz (author);Friedl, Andrée (author);Schlegel, Matthias (author);Vernazza, Pietro (author);Kahlert, Christian R. (author) is a Medicine article available to read on EtoBox.

What is Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study about?

## Abstract ## Background In a prospective healthcare worker (HCW) cohort, we assessed the risk of SARS-CoV-2 infection according to baseline serostatus. ## Methods Baseline serologies were performed among HCW from 23 Swiss healthcare institutions between June and September 2020, before the second COVID-19 wave. Participants answered weekly electronic questionnaires covering information about nasopharyngeal swabs (PCR/rapid antigen tests) and symptoms compatible with coronavirus disease 2019 (COVID-19). Screening of symptomatic staff by nasopharyngeal swabs was routinely performed in participating facilities. We compared numbers of positive nasopharyngeal tests and occurrence of COVID-19 symptoms between HCW with and without anti-nucleocapsid antibodies. ## Results A total of 4812 HCW participated, wherein 144 (3%) were seropositive at baseline. We analyzed 107,807 questionnaires with a median follow-up of 7.9 months. Median number of answered questionnaires was similar (24 vs. 23 per person, P = 0.83) between those with and without positive baseline serology. Among 2712 HCW with ≥ 1 SARS-CoV-2 test during follow-up, 3/67 (4.5%) seropositive individuals reported a positive result (

Who reads Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study?

Author

Kohler, Philipp (author);Güsewell, Sabine (author);Seneghini, Marco (author);Egger, Thomas (author);Leal, Onicio (author);Brucher, Angela (author);Lemmenmeier, Eva (author);Möller, J. Carsten (author);Rieder, Philip (author);Ruetti, Markus (author);Stocker, Reto (author);Vuichard-Gysin, Danielle (author);Wiggli, Benedikt (author);Besold, Ulrike (author);Kuster, Stefan P. (author);McGeer, Allison (author);Risch, Lorenz (author);Friedl, Andrée (author);Schlegel, Matthias (author);Vernazza, Pietro (author);Kahlert, Christian R. (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)