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LC/MS/MS Method for Ganglioside Analysis by Ramona Neka Tamo is a document available to read on EtoBox.
This document describes the development and validation of a new LC/MS/MS method for quantifying four types of gangliosides (GM2, GM3, GD2, GD3) in human plasma. Gangliosides are glycosphingolipids found abundantly in the central nervous system and have been implicated in several neurological disorders. The new method uses protein precipitation for sample extraction from plasma followed by UPLC/MS/MS analysis using multiple reaction monitoring mode for detection. The method was validated for extraction recov
- Author
- Ramona Neka Tamo
- Language
- EN