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Prophylaxis of Oral Mucositis in Irradiated Head-and-neck Cancer Patients: a Proposed Classification Scheme of Interventions and Meta-analysis of Randomized Controlled Trials by Susan E Sutherland; George P Browman is a Medicine article available to read on EtoBox.
What is Prophylaxis of Oral Mucositis in Irradiated Head-and-neck Cancer Patients: a Proposed Classification Scheme of Interventions and Meta-analysis of Randomized Controlled Trials about?
Purpose: To identify, classify, and evaluate agents used in the prophylaxis of oral mucositis in irradiated head and neck cancer patients. Methods: Data sources included multiple databases and manual citation review of relevant literature. Based on the eligibility criteria, 59 studies were independently reviewed by two reviewers. Forty-two studies were included in the classification scheme, of which 15 met the criteria for inclusion in the meta-analysis. Data were extracted by duplicate independent review, with disagreement resolved by consensus. Results: Overall, the interventions reduced the odds of developing severe oral mucositis, when assessed by clinicians, by 36% (OR: 0.64; 95% CI: 0.46, 0.88). Subgroup analysis suggested that only the narrow-spectrum antibacterial lozenges were effective (OR: 0.45; 95% CI: 0.23, 0.86); however, the power of the aggregated data in the other classes may have been insufficient to detect differences. When the outcome was assessed by patients, no significant difference was seen in the outcome between the treatment and the control groups (OR: 0.79; 95% CI: 0.56 -1.12). Conclusions: Overall, interventions chosen on a sound biologic basis to preven
Who reads Prophylaxis of Oral Mucositis in Irradiated Head-and-neck Cancer Patients: a Proposed Classification Scheme of Interventions and Meta-analysis of Randomized Controlled Trials?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Susan E Sutherland; George P Browman
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)