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Can I read Nanofiber-coated implants: Development and safety after intravitreal application in rabbits on EtoBox?
Nanofiber-coated implants: Development and safety after intravitreal application in rabbits by Maria Carolina Andrade Guerra; Julia Teixeira Neto; Michele Gouvea Gomes; Lays Fernanda Nunes Dourado; Rodrigo Lambert Oréfice; Luiz Guilherme Dias Heneine; Armando Silva-Cunha; Silvia Ligorio Fialho is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Nanofiber-coated implants: Development and safety after intravitreal application in rabbits about?
Intravitreal injections are the preferred choice for drug administration to the posterior segment of the eye. However, the required frequent injections may cause complications to the patient and low adherence to the treatment. Intravitreal implants are able to maintain therapeutic levels for a long period. Biodegradable nanofibers can modulate drug release and allow the incorporation of fragile bioactive drugs. Age-related macular degeneration is one of the world major causes of blindness and irreversible vision loss. It involves the interaction between VEGF and inflammatory cells. In this work we developed nanofiber-coated intravitreal implants containing dexamethasone and bevacizumab for simultaneously delivery of these drugs. The implant was successfully prepared and the efficiency of the coating process was confirmed by scanning electron microscopy. Around 68% of dexamethasone was released in 35 days and 88% of bevacizumab in 48hs. The formulation presented activity in the reduction of vessels and was safe to the retina. It was not observed any clinical or histopathological change, neither alteration in retina function or thickness by electroretinogram and optical coherence tom
Who reads Nanofiber-coated implants: Development and safety after intravitreal application in rabbits?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Maria Carolina Andrade Guerra; Julia Teixeira Neto; Michele Gouvea Gomes; Lays Fernanda Nunes Dourado; Rodrigo Lambert Oréfice; Luiz Guilherme Dias Heneine; Armando Silva-Cunha; Silvia Ligorio Fialho
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)