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Central Nervous System (CNS) Involvement in Adult Acute Lymphoblastic Leukemia (ALL) Assessed Solely By Flow Cytometry Has an Adverse Impact on Survival by Rosana Daniela Córdova-Serrano; Emmanuel Almanza Huante; Emmanuel Mártinez-Moreno; Areli Hérnandez-Alcántara; Emmanuel Fernández-Sánchez; Andres Gomez-De Leon; Karla Adriana Espinosa is a Medicine article available to read on EtoBox.
What is Central Nervous System (CNS) Involvement in Adult Acute Lymphoblastic Leukemia (ALL) Assessed Solely By Flow Cytometry Has an Adverse Impact on Survival about?
Introduction: Several studies published in recent years dealing with the detection of Central Nervous System (CNS) disease in Acute Lymphoblastic Leukemia (ALL) have demonstrated superiority in terms of sensitivity of Flow Cytometry (FCM) over standard cytology (Tawfik et al, 2018). However, whether CNS activity detected by FCM has an impact on the clinical outcome of ALL adult patients, is still a matter of debate. (Del Principe et al, 2019) Methodology: We analyzed a retrospective cohort of newly diagnosed ALL adult patients in an oncologic center in Mexico, who had a CNS analysis by FCM and conventional cytology, diagnosed between 2017 and 2019. The primary endpoint was to assess the impact on the survival of patients with CNS disease detected by FCM. We defined positive FCM (FCM+) when the patient had >10 phenotypically pathologic events and positive cytology (Cyt+) when the patent had confirmed CNS-2 or CNS-3 activity as defined by NCCN and ESMO; double-negative (DN) patients were considered when neither FCM nor cytology demonstrated disease as described above. Baseline characteristics were grouped in tables and summarized as medians and ranges for quantitative variables or fr
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- Author
- Rosana Daniela Córdova-Serrano; Emmanuel Almanza Huante; Emmanuel Mártinez-Moreno; Areli Hérnandez-Alcántara; Emmanuel Fernández-Sánchez; Andres Gomez-De Leon; Karla Adriana Espinosa
- Publisher
- American Society of Hematology
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)