Opening book details…
Can I read Precise Regulation of Enzyme–Nanozyme Cascade Reaction Kinetics by Magnetic Actuation toward Efficient Tumor Therapy on EtoBox?
Precise Regulation of Enzyme–Nanozyme Cascade Reaction Kinetics by Magnetic Actuation toward Efficient Tumor Therapy by Ye Zhang; Yanyun Wang; Qi Zhou; Xiaoyong Chen; Wangbo Jiao; Galong Li; Mingli Peng; Xiaoli Liu; Yuan He; Haiming Fan is a Engineering article available to read on EtoBox.
What is Precise Regulation of Enzyme–Nanozyme Cascade Reaction Kinetics by Magnetic Actuation toward Efficient Tumor Therapy about?
Spatiotemporal regulation of multi-enzyme catalysis with stimuli is crucial in nature to meet different metabolic requirements but presents a challenge in artificial cascade systems. Here, we report a strategy for precise and tunable modulation of enzyme-nanozyme cascade reaction kinetics by remote magnetic stimulation. As a proof of concept, glucose oxidase (GOx) was immobilized onto a ferrimagnetic vortex iron oxide nanoring (FeO NR) functionalized with poly(ethylene glycol) of different molecular weights to construct a series of FeO NR@GOx with nanometer linking distances. The activities of GOx and the FeO NR nanozyme in these systems were shown to be differentially stimulated by FeO NR-mediated local heat in response to an alternating magnetic field (AMF), leading to modulated cascade reaction kinetics in a distance-dependent manner. Compared to the free GOx and FeO NR mixture, FeO NR(D2)@GOx with an optimum linking distance of 1 nm exhibits a superior kinetic match between GOx and the FeO NR nanozyme and over a 400-fold higher cascade activity under AMF exposure. This enables remarkable intracellular reactive oxygen species production and significantly improved tumor inhibitio
Who reads Precise Regulation of Enzyme–Nanozyme Cascade Reaction Kinetics by Magnetic Actuation toward Efficient Tumor Therapy?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Ye Zhang; Yanyun Wang; Qi Zhou; Xiaoyong Chen; Wangbo Jiao; Galong Li; Mingli Peng; Xiaoli Liu; Yuan He; Haiming Fan
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)