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Can I read Opposite Effects of Short- and Long-duration Isolation on Ultrasonic Vocalization, Startle and Prepulse Inhibition in Rats on EtoBox?
Opposite Effects of Short- and Long-duration Isolation on Ultrasonic Vocalization, Startle and Prepulse Inhibition in Rats by Fernanda Mariana Tomazini; Adriano Reimer; Lucas Albrechet-Souza; Marcus Lira Brandão is a Neuroscience article available to read on EtoBox.
What is Opposite Effects of Short- and Long-duration Isolation on Ultrasonic Vocalization, Startle and Prepulse Inhibition in Rats about?
Housing conditions change the sensorimotor gating and the emotional state of rats. The prepulse inhibition (PPI) is a reduction in the startle reflex to loud sounds when they are preceded by acoustic stimuli of low-intensity, and this test has been considered to be a useful measurement of the functioning of sensory gating in animals and man. Rats reared under conditions of isolation from the time of weaning, but not for 1 week at adult age, display clear deficits in prepulse inhibition and in sensorimotor gating. Ultrasound vocalizations (USVs) at 20-24kHz are the usual defensive responses of rats exposed to threatening conditions such as novel situations. The amount of emissions of ultrasound vocalizations at these frequencies depends on whether the aversive stimuli are presented either alone or in combination. Given this background we evaluated the prepulse inhibition and the emission of ultrasound vocalizations in response to novelty in rats isolated for 1 day or 2 weeks and compared the results to those in grouped rats. We also examined whether the anxiolytic agent midazolam (0.5 and 1.0mg/kg) could reverse the effects of isolation under the experimental conditions used. Rats i
Who reads Opposite Effects of Short- and Long-duration Isolation on Ultrasonic Vocalization, Startle and Prepulse Inhibition in Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Fernanda Mariana Tomazini; Adriano Reimer; Lucas Albrechet-Souza; Marcus Lira Brandão
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-0270)
- Published
- 2006
- Language
- EN
- Field
- Neuroscience (Life Sciences)