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Characterization of Lineage-specific Chimaerism in Patients with Acute Leukaemia and Myelodysplastic Syndrome After Allogeneic Stem Cell Transplantation Before and After Relapse by P. Bader; K. Stoll; S. Huber; A. Geiselhart; R. Handgretinger; C. Niemeyer; H. Einsele; P. G. Schlegel; D. Niethammer; J. Beck; T. Klingebiel is a Medicine article available to read on EtoBox.
What is Characterization of Lineage-specific Chimaerism in Patients with Acute Leukaemia and Myelodysplastic Syndrome After Allogeneic Stem Cell Transplantation Before and After Relapse about?
Recently, we have shown that patients with acute leukaemias and myelodysplastic syndromes (MDS), who showed increasing mixed chimaerism (MC) upon serial PCR analysis after transplant, have a significantly increased risk of relapse. To determine whether the increasing MC in these patients is caused by the reappearance of normal recipient haematopoiesis or by the reoccurrence of malignant cells, we purified different leucocyte subpopulations and analysed these subfractions with regard to their donor-recipient ratio by a PCR-based method for the analysis of minisatellite DNA regions. In 14 patients [eight acute lymphoblastic leukaemia (ALL), three acute myelogenous leukaemia (AML) and three MDS] subfractions were analysed when increasing MC was first noted upon serial analysis of the peripheral blood. In seven of these 14 patients (four ALL, two AML and one MDS), subfractions were characterized at the time of frank haematological relapse. In all 14 patients investigated with increasing MC, recipient cells were detected in different mononuclear cell subpopulations. In patients characterized during frank relapse, two distinct distribution patterns were found. Patients who relapsed befor
Who reads Characterization of Lineage-specific Chimaerism in Patients with Acute Leukaemia and Myelodysplastic Syndrome After Allogeneic Stem Cell Transplantation Before and After Relapse?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- P. Bader; K. Stoll; S. Huber; A. Geiselhart; R. Handgretinger; C. Niemeyer; H. Einsele; P. G. Schlegel; D. Niethammer; J. Beck; T. Klingebiel
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)