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Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study by Egbert Herting; for the German Neonatal Network (GNN); Angela Kribs; Christoph Härtel; Axel von der Wense; Ursula Weller; Thomas Hoehn; Matthias Vochem; Jens Möller; Christian Wieg; Bernhard Roth; Wolfgang Göpel is a Medicine article available to read on EtoBox.
What is Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study about?
Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (__n__ = 95) and the control group (__n__ = 84) that received standard treatment. __Conclusion__: No differences in outcome were observed at 2 years. LISA seems safe in that aspect. |**What is Known:**• __LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.__ | | --- | |**What is New:**• __Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.__ |
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- Author
- Egbert Herting; for the German Neonatal Network (GNN); Angela Kribs; Christoph Härtel; Axel von der Wense; Ursula Weller; Thomas Hoehn; Matthias Vochem; Jens Möller; Christian Wieg; Bernhard Roth; Wolfgang Göpel
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)