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Elevated Serum Levels of Transforming Growth Factor-beta1 in Patients with Colorectal Carcinoma: Its Association with Tumor Progression and Its Significant Decrease After Curative Surgical Resection by Kang Sup Shim; Kwang Ho Kim; Woon Sup Han; Eung Bum Park is a Medicine article available to read on EtoBox.

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## Background: Transforming growth factor-beta1 (tgf-beta1) acts as a potent inhibitor of cell growth and tumor progression but loss of this negative regulation can contribute to tumor development. some studies have reported an association between disease progression and tgf-beta1 expression in patients with colorectal carcinoma, but their results were not always consistent. ## Methods: Serum levels of tgf-beta1 were measured using an enzyme-linked immunoadsorbent assay in 121 consecutive patients with colorectal carcinoma and compared with tgf-beta1 serum levels in 31 healthy volunteers. serum levels of tgf-beta1 also were measured in 50 patients who underwent curative surgical resection (part of the 121 preoperative patients) to compare their levels with preoperative serum levels of tgf-beta1. ## Results: Serum levels of tgf-beta1 in patients with colorectal carcinoma (45+/-15 ng/ml) (mean+/-the standard deviation) were significantly higher than those in the healthy control group (32+/-4 ng/ml) (p = 0.001). serum levels of tgf-beta1 increased with increasing tumor stage (p < 0.01). serum levels of tgf-beta1 were correlated significantly with depth of tumor invasion, lymph node me

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Author

Kang Sup Shim; Kwang Ho Kim; Woon Sup Han; Eung Bum Park

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1999

Language

EN

Field

Medicine (Health Sciences)