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The Alkaloids: Antitumor Bisindole Alkaloids from Catharanthus roseus (L.) V37, Volume 37 by Arnold Brossi and Matthew Suffness (Eds.) is a nonfiction available to read on EtoBox.

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Front Cover 1 The Alkaloids, Volume 37 4 Copyright Page 5 CONTENTS 6 Contributors 8 Preface 10 Chapter 1. Isolation, Structure Elucidation, and Biosynthesis of the Bisindole Alkaloids of Catharanthus 12 I. Introduction 12 II. Structure Elucidation and Spectroscopy 16 III. Biosynthesis 47 IV. Summary 78 References 80 Chapter 2. Syntheses of Vinblastine-Type Alkaloids 88 I. Introduction 88 II. Hydroxyalkylindole Route 90 III. Chloroindolenine Route 92 IV. β-Carboline Coupling 100 V. Biomimetic Approach 100 VI. New Strategies for Generation of C-16'–C-14' PARF Relative Stereochemistry 116 References 138 Chapter 3. Functional Hot Spot at the C-20' Position of Vinblastine 144 I. Introduction 144 II. C-20' Modifications 145 III. Molecular Constraints of Congener Activity 153 IV. Conclusions 155 References 155 Chapter 4. Medicinal Chemistry of Bisindole Alkaloids From Catharanthus 156 I. Introduction 156 II. Pharmacology 158 III. Physicochemical Considerations 160 IV. Naturally Occurring Bisindole Alkaloids from Catharanthus 164 V. Modifications of the Upper Half (Velbanamine Portion) of Bisindole Alkaloids 166 VI. Modifications of the Lower Half (Vindoline Portion) of Bisindole Alkaloids

Who reads The Alkaloids: Antitumor Bisindole Alkaloids from Catharanthus roseus (L.) V37, Volume 37?

Author

Arnold Brossi and Matthew Suffness (Eds.)

Publisher

Elsevier, Academic Press

Published

1990

Language

EN

ISBN

9780124695290

Category

nonfiction

Subjects

Science, Chemistry, Medical