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Analysis of Metastases in Non-small Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Mutation by Yu Chen; Juan Deng; Yu Liu; Hao Wang; Sha Zhao; Yayi He; Caicun Zhou is a Medicine article available to read on EtoBox.

What is Analysis of Metastases in Non-small Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Mutation about?

## Background Most lung cancer patients are diagnosed at an advanced stage with metastases. There was no population-based data on metastases in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (__EGFR__) mutation. This study focused on the metastases in NSCLC patients with __EGFR__ mutation. ## Methods In our research, we retrospectively studied 365 NSCLC patients with __EGFR__ mutation (__EGFR__ positive-mutant group) were not resistant to first-generation __EGFR__ TKIs and 316 NSCLC patients with T790M mutation (T790M-mutant group) who were resistant to first-generation __EGFR__ TKIs. In the study, we also investigated sex, smoking status, age at diagnosis, histology, T, N, and M stage, and mutation status. In addition, we analyzed metastatic sites in stage IV patients. ## Results Among the __EGFR__ positive-mutant group, 248 (67.95%) patients were stage IV disease. Among them, 41 patients had brain metastases, 86 patients had bone metastases, 16 patients had liver metastases, 168 patients had intrapulmonary metastases, and 39 patients had metastases in other sites. Among the T790M-mutant group, 277 (87.66%) patients were stage IV disease. Among t

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Author

Yu Chen; Juan Deng; Yu Liu; Hao Wang; Sha Zhao; Yayi He; Caicun Zhou

Publisher

AME Publishing Company

Published

2021

Field

Medicine (Health Sciences)