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KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone by Konstantinos Mavridis; Maroulio Talieri; Andreas Scorilas is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone about?

## Abstract Kallikrein-related peptidases (KLKs), including__KLK5__, have been proposed as promising biomarkers for prostate cancer diagnosis and prognosis. In the present study, we report that distinct augmentations (up to 6.4-fold) of__KLK5__mRNA expressional levels, calculated via quantitative real-time PCR, occur after treatment of DU145 cells with appropriate concentrations, determined by the MTT method, of docetaxel and mitoxantrone. Our data reveal the endogenous need of prostate cancer cells for modified__KLK5__expression to cope with the administration of chemotherapeutic drugs. Furthermore, it is proposed that the expression profile of__KLK5__could serve as a putative biomarker for monitoring the treatment response in hormone refractory prostate cancer patients.

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Author

Konstantinos Mavridis; Maroulio Talieri; Andreas Scorilas

Publisher

Walter de Gruyter GmbH

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)