Can I read Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites on EtoBox?

Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites by Josiemer Mattei; Laurence D Parnell; Chao-Qiang Lai; Bibiana Garcia-Bailo; Xian Adiconis; Jian Shen; Donna Arnett; Serkalem Demissie; Katherine L Tucker; Jose M Ordovas is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites about?

## Abstract ## Background Variations in gene allele frequencies can contribute to differences in the prevalence of some common complex diseases among populations. Natural selection modulates the balance in allele frequencies across populations. Population differentiation (F~ST~) can evidence environmental selection pressures. Such genetic information is limited in Puerto Ricans, the second largest Hispanic ethnic group in the US, and a group with high prevalence of chronic disease. We determined allele frequencies and population differentiation for 101 single nucleotide polymorphisms (SNPs) in 30 genes involved in major metabolic and disease-relevant pathways in Puerto Ricans (n = 969, ages 45–75 years) and compared them to similarly aged non-Hispanic whites (NHW) (n = 597). ## Results Minor allele frequency (MAF) distributions for 45.5% of the SNPs assessed in Puerto Ricans were significantly different from those of NHW. Puerto Ricans carried risk alleles in higher frequency and protective alleles in lower frequency than NHW. Patterns of population differentiation showed that Puerto Ricans had SNPs with exceptional F~ST~ values in intronic, non-synonymous and promoter regions. NHW

Who reads Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites?

Author

Josiemer Mattei; Laurence D Parnell; Chao-Qiang Lai; Bibiana Garcia-Bailo; Xian Adiconis; Jian Shen; Donna Arnett; Serkalem Demissie; Katherine L Tucker; Jose M Ordovas

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2156)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)