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Factors influencing the incidence of Hirschsprung associated enterocolitis (HAEC) by Annie Le-Nguyen; Franziska Righini-Grunder; Nelson Piché; Christophe Faure; Ann Aspirot is a Medicine article available to read on EtoBox.

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## Purpose: This study aims to characterize risk factors for hirschsprung-associated enterocolitis (haec). we hypothesize that earlier pull-through surgery is associated with lower risks of developing postoperative haec. ## Methods: A comparative study of 171 hirschsprung patients treated from 1990 to 2017 was performed. patients without haec were compared to patients with preoperative and/or postoperative haec. results are presented as median [iqr] or frequency (%). pearson's χ test and wilcoxon rank sum test were performed with a significance level at p < 0.05. multivariable logistic regression analysis was used to adjust for potential confounders. a subanalysis was done to evaluate laparoscopic, laparotomy, and transanal surgeries. ## Results: Risk of developing preoperative haec was significantly associated with congenital malformations (or 2.63 [1.11, 6.24]; p = 0.02). birth weight was lower in patients with preoperative haec (or 0.48 [95% ci 0.25, 0.93]; p = 0.03). on regression analysis, intestinal obstruction after surgery was significantly associated with postoperative haec (or 8.2 [3.18, 21.13]; p < 0.0001). patients with earlier pull-through surgery did not have a lower

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Author

Annie Le-Nguyen; Franziska Righini-Grunder; Nelson Piché; Christophe Faure; Ann Aspirot

Publisher

Elsevier BV

Published

2019

Language

EN

Field

Medicine (Health Sciences)