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Effect of Dexamethasone on Pulmonary Surfactant Metabolism in Hyperoxia-Treated Rat Lungs by Tamaki Ohashi; Satoshi Takada; Toshiyuki Motoike; Syuichi Tsuneishi; Masafumi Matsuo; Kimihiko Sano; Hajime Nakamura is a Medicine article available to read on EtoBox.

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We have examined the effect of dexamethasone on the metabolism of pulmonary surfactant in normal and hyperoxia-treated rats. The relative abundance of the surfactant-specific apoprotein A (SP-A) mRNA in lung tissues and the contents of disaturated phosphatidylcholine (DSPC) and SP-A were measured in bronchoalveolar lavage fluids and in lung tissues in 4-wk-old rats exposed to room air or greater than 90% oxygen for 7 d with or without simultaneous treatment with dexamethasone (0.5 mg/kg body wt for 7 d). The relative abundance of the SP-A mRNA was marginally increased by hyperoxia (1.3-fold over controls). Dexamethasone increased the relative abundance of the SP-A mRNA to a level comparable to that with hyperoxia treatment (1.5-fold over controls). In lavage fluids, the contents of DSPC and SP-A were increased by 4- and 6-fold over controls by hyperoxia, respectively, but they were increased only by 2-fold by dexamethasone. In lung tissues, the contents of DSPC and SP-A were increased by 3- and 2-fold over controls by hyperoxia, respectively. These values in lung tissues in the air-exposed rats were not significantly increased by dexamethasone. In hyperoxia-treated rats, dexamethas

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Author

Tamaki Ohashi; Satoshi Takada; Toshiyuki Motoike; Syuichi Tsuneishi; Masafumi Matsuo; Kimihiko Sano; Hajime Nakamura

Publisher

Springer Science and Business Media LLC

Published

1991

Language

EN

Field

Medicine (Health Sciences)