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Primary effusion lymphoma : A series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis by Fadi Brimo; René P. Michel; Karim Khetani; Manon Auger is a Medicine article available to read on EtoBox.

What is Primary effusion lymphoma : A series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis about?

BACKGROUND. Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV-8)-associated and very rare type of lymphoma usually confined to the body cavities and commonly observed in human immunodeficiency virus (HIV)infected patients. A comparison was made between the cytologic and immunocytochemical features of 4 cases of PEL encountered in the authors' department with those reported to date in the literature. ## METHODS. A comprehensive comparison of the cytologic and immunocytochemical features of the 4 cases with those reported in the literature was conducted. ## RESULTS. Cytologically, the most consistent features of the 4 cases and those in the literature included large cell size, moderate to abundant cytoplasm, a single nucleus in most cells with occasional bi-or multinucleated giant cells, single to multiple prominent nucleoli, and coarse chromatin. Immunocytochemically, only 2 (50%) of the current cases were of the null-phenotype compared with 93% of cases in the literature; the other 2 cases had a T-cell phenotype. Activation markers were expressed in 50% and 78% of the current cases and the literature cases, respectively. Positivity for HHV-8 was proven in the 4 cases b

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Author

Fadi Brimo; René P. Michel; Karim Khetani; Manon Auger

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2007

Language

EN

Field

Medicine (Health Sciences)