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An Analysis of Dose-Staged Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations by J. Jaboin; R. James; B. Stallmeyer; N. Shaw; R. Slawson; P. Amin; L.S. Chin; J. Simard; W.F. Regine is a Medicine article available to read on EtoBox.

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males and 6 females with a median age at diagnosis of 19 yrs (range, 9 -27 yrs). Eight patients (44%) received chemotherapy prior to focal radiation. Ten patients (56%) received CSI. The median dose to the primary tumor was 30 Gy (range, and the median dose to the spine was 24 Gy (range, 20 -30 Gy). The median follow-up was 107 mos (range, 28 -213 mos). Results: The actuarial 10-year survival was 89%. The 10-year local control rate in the brain for patients treated with focal irradiation was 67% compared to 100% in patients treated with CSI (pϭ0.20). The rate of distant control in the spine at 5 years was 87.5% for patients treated with focal irradiation and 100% for patients treated with CSI (pϭ0.29). However, effective salvage was achieved with chemotherapy and CSI in 1 patient who failed in the brain and 1 patient who failed in the spine. Conclusions: While focal techniques of irradiation combined with chemotherapy are attractive and becoming increasingly adopted, its use appears to be associated with increased rates of failures in the brain and spine compared to CSI. More vigilance may be required in the follow-up monitoring of patients treated with focal irradiation techniques

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Author

J. Jaboin; R. James; B. Stallmeyer; N. Shaw; R. Slawson; P. Amin; L.S. Chin; J. Simard; W.F. Regine

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2005

Language

EN

Field

Medicine (Health Sciences)