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MACOP-B and Involved-Field Radiotherapy Is an Effective and Safe Therapy for Primary Mediastinal Large B Cell Lymphoma by Vitaliana De Sanctis; Erica Finolezzi; Mattia Falchetto Osti; Lavinia Grapulin; Marco Alfò; Edoardo Pescarmona; Francesca Berardi; Fiammetta Natalino; Maria Luisa Moleti; Alice Di Rocco; Riccardo Maurizi Enrici; Robin Foà; Maurizio Martelli is a Medicine article available to read on EtoBox.

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Purpose: To report the clinical findings and long-term results of front-line, third-generation MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin) chemotherapy and mediastinal involved-field radiotherapy (IFRT) in 85 consecutive, previously untreated patients with primary mediastinal large B cell lymphoma (PMLBCL) diagnosed and managed at a single institution. Methods and Materials: Between 1991 and April 2004, 92 consecutive, untreated patients with PMLBCL were treated at our institution. The median age was 33 years (range, 15-61 years), 46 patients (50%) showed a mediastinal syndrome at onset; 52 patients (57%) showed a low/low-intermediate (0 to 1) and 40 patients (43%) an intermediate-high/high (2 to 3) International Prognostic Index (IPI) score. Eighty-five patients were treated with standard chemotherapy (MACOP-B), and 80 underwent mediastinal IFRT at a dose of 30-36 Gy. Results: After a MACOP-B regimen, the overall response rate was 87% and the partial response rate 9%. After chemotherapy, 67 Ga scintigraphy/positron emission tomography results were positive in 43 of 52 patients (83%), whereas after IFRT 11 of 52 patients (21%) remai

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Author

Vitaliana De Sanctis; Erica Finolezzi; Mattia Falchetto Osti; Lavinia Grapulin; Marco Alfò; Edoardo Pescarmona; Francesca Berardi; Fiammetta Natalino; Maria Luisa Moleti; Alice Di Rocco; Riccardo Maurizi Enrici; Robin Foà; Maurizio Martelli

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2008

Language

EN

Field

Medicine (Health Sciences)