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Changes in Localization of Immune Cells and Cytokines in Corpora Lutea During Luteolysis in Murine Ovaries by Kohji Komatsu; Noboru Manabe; Minako Kiso; Munetake Shimabe; Hajime Miyamoto is a Environmental Science article available to read on EtoBox.

What is Changes in Localization of Immune Cells and Cytokines in Corpora Lutea During Luteolysis in Murine Ovaries about?

Immune cells, which constitute a significant cell mass in the corpora lutea (CLs), are considered to play critical roles in luteolysis, but the details are not fully understood. We histochemically investigated the changes in distribution and cell density of macrophages and T lymphocytes and in tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, which can induce apoptosis in the luteal cells in murine CLs during luteal regression. No macrophages or T lymphocytes were observed in functionally healthy CLs. Abundant macrophages and increasing T lymphocytes were demonstrated in CLs at the functional regression stage (early stage of regression). At the structural regression stage (late stage of regression), abundant T lymphocytes but no macrophages were demonstrated in the CLs. A moderate amount of TNF-alpha was detected in all CLs at all stages. No IFN-gamma was detected in either healthy or early regressing CLs, but a large amount of IFN-gamma was detected at the late regression stage. Moreover, in cultured luteal cells, reactivity against Fas-ligand (FasL) was caused by pretreatment with TNF-alpha and IFN-gamma and apoptosis was induced by FasL treatment. These findings supp

Who reads Changes in Localization of Immune Cells and Cytokines in Corpora Lutea During Luteolysis in Murine Ovaries?

Author

Kohji Komatsu; Noboru Manabe; Minako Kiso; Munetake Shimabe; Hajime Miyamoto

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)

Published

2003

Language

EN

Field

Environmental Science (Life Sciences)