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This research article presents a novel ovine model of hypertensive heart failure with preserved ejection fraction (HFpEF) developed in older female sheep. The model demonstrates key characteristics of HFpEF, including diastolic dysfunction, concentric left ventricular hypertrophy, and impaired exercise capacity, which are similar to those observed in human patients. This model may serve as a valuable tool for understanding HFpEF mechanisms and developing effective therapies.

Author

yamabesharat2006

Language

EN