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Can I read Protochordate Zic genes define primitive somite compartments and highlight molecular changes underlying neural crest evolution on EtoBox?
Protochordate Zic genes define primitive somite compartments and highlight molecular changes underlying neural crest evolution by Neil J. Gostling; Sebastian M. Shimeld is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Protochordate Zic genes define primitive somite compartments and highlight molecular changes underlying neural crest evolution about?
**SUMMARY** The vertebrate Zic gene family encodes C2H2 zinc finger transcription factors closely related to the Gli proteins. Zic genes are expressed in multiple areas of developing vertebrate embryos, including the dorsal neural tube where they act as potent neural crest inducers. Here we describe the characterization of a Zic ortholog from the amphioxus __Branchiostoma floridae__ and further describe the expression of a Zic ortholog from the ascidian __Ciona intestinalis.__ Molecular phylogenetic analysis and sequence comparisons suggest the gene duplications that formed the vertebrate Zic family were specific to the vertebrate lineage. In __Ciona__ maternal __CiZic/Ci‐macho1__ transcripts are localized during cleavage stages by asymmetric cell division, whereas zygotic expression by neural plate cells commences during neurulation. The amphioxus Zic ortholog __AmphiZic__ is expressed in dorsal mesoderm and ectoderm during gastrulation, before being eliminated first from midline cells and then from all neurectoderm during neurulation. After neurulation, expression is reactivated in the dorsal neural tube and dorsolateral somite. Comparison of __CiZic__ and __AmphiZic__ expression
Who reads Protochordate Zic genes define primitive somite compartments and highlight molecular changes underlying neural crest evolution?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Neil J. Gostling; Sebastian M. Shimeld
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1520-541X)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)