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Can I read Developmental regulation and asymmetric expression of the gene encoding Cx43 gap junctions in the mouse limb bud on EtoBox?
Developmental regulation and asymmetric expression of the gene encoding Cx43 gap junctions in the mouse limb bud by Rita A. Meyer; Matthew F. Cohen; Scott Recalde; Jozsef Zakany; Sheila M. Bell; William J. Scott Jr.; Cecilia W. Lo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Developmental regulation and asymmetric expression of the gene encoding Cx43 gap junctions in the mouse limb bud about?
The Gja1 gene encoding the gap junction connexin 43 (Cx43) is dynamically regulated during limb morphogenesis. Transcript expression is found in many regions of the limb bud known to be important in regulating limb growth and patterning. In the newly emerged limb bud, Gja1 transcripts are first expressed in the ventrodistal margin of the ectoderm, and later transcript expression is localized to the apical ectodermal ridge (AER). Interestingly, transcript expression in the ventrodistal ectoderm is initiated left/right asymmetrically, with some strain backgrounds showing reverse sidedness in the fore vs. hindlimb buds. In legless, a mouse mutant exhibiting both limb and left/ right patterning defects, Gja1 transcripts could not be detected in this region. However, in the iv/iv embryo, a mutant with randomization of body situs, the same pattern of Gja1 asymmetry was found in the limb ectoderm regardless of body situs. This suggests that Gja1 transcript expression is not directly linked to signaling pathways involved in specification of the left/right axis. In addition to transcript expression in the apical ectodermal ridge, Gja1 transcripts were also found at high levels in the ventra
Who reads Developmental regulation and asymmetric expression of the gene encoding Cx43 gap junctions in the mouse limb bud?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Rita A. Meyer; Matthew F. Cohen; Scott Recalde; Jozsef Zakany; Sheila M. Bell; William J. Scott Jr.; Cecilia W. Lo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0192-253X)
- Published
- 1997
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)