About this Medicine article

Fecal Calprotectin Mirrors Inflammation of the Distal Ileum and Bowel Function After Restorative Proctocolectomy for Pediatric-onset Ulcerative Colitis† by Mikko P. Pakarinen; Antti Koivusalo; Johanna Natunen; Merja Ashorn; Riitta Karikoski; Petri Aitola; Risto J. Rintala; Kaija-Leena Kolho is a Medicine article available to read on EtoBox.

## Background: The goal was to cross-sectionally assess fecal calprotectin after restorative proctocolectomy for pediatric-onset ulcerative colitis (uc). ## Methods: Fecal calprotectin, histology of the distal ileum, inflammation biochemistry, episodes of pouchitis, and bowel function were cross-sectionally determined at early adulthood in 32 patients who had undergone proctocolectomy with ileoanal anastomosis for uc at a mean (sd) age of 12.0 +/- 4.1 years. ## Results: A total of 15 (47%) patients showed increased (>100 microg/g) fecal calprotectin (669 +/- 866 microg/g), although their serum c-reactive protein (5.2 +/- 3.8 mg/l), erythrocyte sedimentation rate (13 +/- 13 mm/h), and white blood cell count (6.7 +/- 1.7 e9/l) were normal or slightly elevated. calprotectin correlated positively with the histological neutrophil count of the distal ileum (r = 0.715; p < 0.001), the frequency of pouchitis (r = 0.468; p < 0.01), and with the maximum daily frequency of bowel actions (r = 0.610; p < 0.001). mean fecal calprotectin was 71 +/- 50 microg/g among patients with no history of pouchitis (n = 10), 290 +/- 131 microg/g among patients with a single episode of pouchitis (n = 15), and

Author

Mikko P. Pakarinen; Antti Koivusalo; Johanna Natunen; Merja Ashorn; Riitta Karikoski; Petri Aitola; Risto J. Rintala; Kaija-Leena Kolho

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP) (ISSN 1078-0998)

Published

2010

Language

EN

Field

Medicine (Health Sciences)