Can I read Electrolytic Deposition of Calcium Etidronate Drug Coating on Titanium Substrate on EtoBox?

Electrolytic Deposition of Calcium Etidronate Drug Coating on Titanium Substrate by Ke Duan; Yuwei Fan; Rizhi Wang is a Medicine article available to read on EtoBox.

What is Electrolytic Deposition of Calcium Etidronate Drug Coating on Titanium Substrate about?

## Abstract Wear debris‐induced osteolysis is the major cause of aseptic loosening and failure of hip implants. One of the promising therapeutic interventions to improve the longevity of hip implants is to administrate bisphosphonate drug to inhibit osteoclastic bone resorption. This study aimed at developing new techniques of directly combining bisphosphonate with implants to achieve local delivery and controlled release of the drug. Instead of using soluble sodium salt, we proposed to apply sparingly soluble calcium salt of bisphosphonate as a potential long‐term antiosteolysis coating on hip implants. Calcium salt of etidronate, a member of the bisphosphonate family of potent osteoclast inhibitors, was used in this pilot study. By adopting the electrolytic deposition (ELD) technique, which was developed for ceramic coatings including calcium phosphates, we demonstrated that a thin layer of calcium bisphosphonate could be deposited onto titanium surface. The drug coating is amorphous as characterized with X‐ray diffraction, and has globular morphology under the scanning electron microscope. Electrospray‐ionization mass‐spectrometry (ESI‐MS) and Fourier‐transformed infrared spectr

Who reads Electrolytic Deposition of Calcium Etidronate Drug Coating on Titanium Substrate?

Author

Ke Duan; Yuwei Fan; Rizhi Wang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2004

Language

EN

Field

Medicine (Health Sciences)