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Can I read IFN‐γ and androgens disrupt mitochondrial function in murine myocytes on EtoBox?
IFN‐γ and androgens disrupt mitochondrial function in murine myocytes by John M Fenimore; Danielle A Springer; Maria E Romero; Elijah F Edmondson; Dan W McVicar; Sudhirkumar Yanpallewar; Michael Sanford; Thea Spindel; Elizabeth Engle; Thomas J Meyer; Julio C Valencia; Howard A Young is a Medicine article available to read on EtoBox.
What is IFN‐γ and androgens disrupt mitochondrial function in murine myocytes about?
The effect of cytokines on non-traditional immunological targets under conditions of chronic inflammation is an ongoing subject of study. Fatigue is a symptom often associated with autoimmune diseases. Chronic inflammatory response and activated cell-mediated immunity are associated with cardiovascular myopathies which can be driven by muscle weakness and fatigue. Thus, we hypothesize that immune dysfunction-driven changes in myocyte mitochondria may play a critical role in fatigue-related pathogenesis. We show that persistent low-level expression of IFN-γ in designated IFN-γ AU-Rich Element deletion mice (ARE mice) under androgen exposure resulted in mitochondrial and metabolic deficiencies in myocytes from male or castrated ARE mice. Most notably, echocardiography unveiled that low ejection fraction in the left ventricle post-stress correlated with mitochondrial deficiencies, explaining how heart function decreases under stress. We report that inefficiencies and structural changes in mitochondria, with changes to expression of mitochondrial genes, are linked to male-biased fatigue and acute cardiomyopathy under stress. Our work highlights how male androgen hormone backgrounds and
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- Author
- John M Fenimore; Danielle A Springer; Maria E Romero; Elijah F Edmondson; Dan W McVicar; Sudhirkumar Yanpallewar; Michael Sanford; Thea Spindel; Elizabeth Engle; Thomas J Meyer; Julio C Valencia; Howard A Young
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)