Opening book details…
Can I read Synthesis and Characterization of New Copper– and Zinc–chloroquine Complexes and Their Activities on Respiratory Burst of Polymorphonuclear Leukocytes on EtoBox?
Synthesis and Characterization of New Copper– and Zinc–chloroquine Complexes and Their Activities on Respiratory Burst of Polymorphonuclear Leukocytes by Maribel Navarro; Helen Goitia; Pedro Silva; Mait Velásquez; Luis E. Ojeda; Germán Fraile is a Chemistry article available to read on EtoBox.
What is Synthesis and Characterization of New Copper– and Zinc–chloroquine Complexes and Their Activities on Respiratory Burst of Polymorphonuclear Leukocytes about?
The metal-chloroquine (CQ) complexes, Cu(CQ) 2 Cl (1), Cu(CQ)(PPh 3 )(NO 3 ) (2), [Cu(OAc) ), were synthesized and characterized by NMR, FAB-mass, elemental analysis, and UV-Vis, EPR and IR spectroscopies. The effects of these compounds on the generation of reactive oxygen species (ROS) from human neutrophils (PMNs) were tested in the concentration range 1-100 lM and compared to that of chloroquine. The data show that the copperchloroquine complexes 1-3 inhibit neutrophil release of ROS in PMNs activated either by a phorbol ester or by phagocytosable particles. Both effects were dose-dependent, with an IC 50 of $10 lM. With the same stimulants, there was only modest inhibition of ROS generation by any of the zinc-chloroquine complexes 4-5 at 10-100 lM. All complexes did not show significant in vitro toxicity as assayed by the trypan blue exclusion method. Our results reinforce previous observations that many metal derivatives of anti-inflammatory drugs affect neutrophil functions with higher potency than their parent ligands.
Who reads Synthesis and Characterization of New Copper– and Zinc–chloroquine Complexes and Their Activities on Respiratory Burst of Polymorphonuclear Leukocytes?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Maribel Navarro; Helen Goitia; Pedro Silva; Mait Velásquez; Luis E. Ojeda; Germán Fraile
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-0134)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)