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Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau by Xuling Li; Peng Lei; Qingzhang Tuo; Scott Ayton; Qiao-Xin Li; Steve Moon; Irene Volitakis; Rong Liu; Colin L. Masters; David I. Finkelstein; Ashley I. Bush is a Medicine article available to read on EtoBox.
What is Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau about?
The amyloid cascade hypothesis of Alzheimer's disease (AD) positions tau protein as a downstream mediator of β-amyloid (Aβ) toxicity This is largely based on genetic cross breeding, which showed that tau ablation in young (3-7-month-old) transgenic mice overexpressing mutant amyloid precursor protein (APP) abolished the phenotype of the APP AD model. This evidence is complicated by the uncertain impact of overexpressing mutant APP, rather than Aβ alone, and for potential interactions between tau and overexpressed APP. Cortical iron elevation is also implicated in AD, and tau promotes iron export by trafficking APP to the neuronal surface. Here, we utilized an alternative model of Aβ toxicity by directly injecting Aβ oligomers into the hippocampus of young and old wild-type and tau knockout mice. We found that ablation of tau protected against Aβ-induced cognitive impairment, hippocampal neuron loss, and iron accumulation. Despite injected human Aβ being eliminated after 5 weeks, enduring changes, including increased APP levels, tau reduction, tau phosphorylation, and iron accumulation, were observed. While the results from our study support the amyloid cascade hypothesis, they also
Who reads Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Xuling Li; Peng Lei; Qingzhang Tuo; Scott Ayton; Qiao-Xin Li; Steve Moon; Irene Volitakis; Rong Liu; Colin L. Masters; David I. Finkelstein; Ashley I. Bush
- Publisher
- Springer Science and Business Media LLC
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)