Can I read Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments on EtoBox?

Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments by César Garriga; María Jesús Pérez-Elías; Rafael Delgado; Lidia Ruiz; Rafael Nájera; Tomàs Pumarola; María del Mar Alonso-Socas; Silvia García-Bujalance; Luis Menéndez-Arias is a Medicine article available to read on EtoBox.

What is Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments about?

## Abstract Human immunodeficiency virus type 1 (HIV‐1) antiviral drug resistance is a major consequence of therapy failure and compromises future therapeutic options. Nelfinavir and lopinavir/ritonavir‐based therapies have been widely used in the treatment of HIV‐infected patients, in combination with reverse transcriptase inhibitors. The aim of this observational study was the identification and characterization of mutations or combinations of mutations associated with resistance to nelfinavir and lopinavir/ritonavir in treated patients. Nucleotide sequences of 1,515 subtype B HIV‐1 isolates from 1,313 persons with different treatment histories (including naïve and treated patients) were collected in 31 Spanish hospitals over the years 2002–2005. Chi‐square contingency tests were performed to detect mutations associated with failure to protease inhibitor‐based therapies, and correlated mutations were identified using statistical methods. Virological failure to nelfinavir was associated with two different mutational pathways. D30N and N88D appeared mostly in patients without previous exposure to protease inhibitors, while K20T was identified as a secondary resistance mutation in t

Who reads Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments?

Author

César Garriga; María Jesús Pérez-Elías; Rafael Delgado; Lidia Ruiz; Rafael Nájera; Tomàs Pumarola; María del Mar Alonso-Socas; Silvia García-Bujalance; Luis Menéndez-Arias

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2007

Language

EN

Field

Medicine (Health Sciences)