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Cellular Therapy for Myocardial Ischemia Using a Temperature-responsive Biodegradable Injectable Polymer System with Adipose-derived Stem Cells by Yuta Yoshizaki; Masaaki Ii; Hiroki Takai; Nozomi Mayumi; Soichiro Fujiwara; Akinori Kuzuya; Yuichi Ohya is a Materials Science article available to read on EtoBox.

What is Cellular Therapy for Myocardial Ischemia Using a Temperature-responsive Biodegradable Injectable Polymer System with Adipose-derived Stem Cells about?

## ABSTRACT Adipose-derived stem cell (AdSC) has been attracting attention as a convenient stem cell source. Not only AdSC can differentiate into various tissue cells, but it can also accelerate cell proliferation, anti-inflammation, and angiogenesis by secreting paracrine factors. Studies have demonstrated AdSC treatment of ischemic heart. However, an improvement in the remaining live AdSCs administered at the injected site while maintaining paracrine factor secretion is desired to achieve effective regenerative medicine. We previously reported the ABA-type tri-block copolymer of poly(ɛ-caprolactone-__co__-glycolic acid) and poly(ethylene glycol) (tri-PCG), exhibiting temperature-responsive sol-to-gel transition as biodegradable injectable polymer (IP) systems. Moreover, we recently reported that the biodegradable temperature-triggered chemically cross-linked gelation systems exhibited longer gel state durations using tri-PCG attaching acryloyl groups and a polythiol derivative. In this study, we explored this IP-mediated AdSC delivery system. We investigated the cell viability, mRNA expression, and cytokine secretion of AdSCs cultured in the physical or chemical IP hydrogels. Bot

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Author

Yuta Yoshizaki; Masaaki Ii; Hiroki Takai; Nozomi Mayumi; Soichiro Fujiwara; Akinori Kuzuya; Yuichi Ohya

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)