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Exploring the quorum sensing inhibition of isolated chrysin from Penicillium chrysogenum DXY-1 by Aiping Chang; Qiaomei He; Li Li; Xiaodan Yu; Shiwei Sun; Hu Zhu is a Chemistry article available to read on EtoBox.

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We recently and for the first time reported that ethyl acetate extracts isolated from Penicillium chrysogenum DXY-1 exhibited anti-quorum sensing (anti-QS) activity. Herein, another active molecule in the extracts was identified as chrysin by NMR and MS. A 20 μg/mL dose of chrysin inhibited violacein production regulated by QS in C. violaceum CV026 by 31.6%. A 40 μg/mL dose of chrysin suppressed pyocyanin production, elastase activity, proteolytic activity, and biofilm formation regulated by QS in P. aeruginosa PA01 by 41.4%, 13.8%, 8.3%, and 42.4%, respectively. And chrysin could inhibit the swarming activity of P. aeruginosa PA01. Further, molecular docking and CD analysis were used to address the mechanism of chrysin's activity in C. violaceum. Molecular docking results revealed that chrysin suppresses QS system by competing with the natural signal molecule C 6 HSL for binding to the same pocket of CviR receptor. At the same time, CD results also showed that chrysin could change the secondary structure composition of CviR, which greatly prevented the binding of C 6 HSL/CviR, and further playing its role on inhibiting bacterial QS system. All these data demonstate that chrysin ma

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Author

Aiping Chang; Qiaomei He; Li Li; Xiaodan Yu; Shiwei Sun; Hu Zhu

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Chemistry (Physical Sciences)