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Cloning and Functional Characterisation of Two Novel Nicotinic Acetylcholine Receptor α Subunits from the Insect Pest Myzus persicae by F. Sgard; S. P. Fraser; M. J. Katkowska; M. B. A. Djamgoz; S. J. Dunbar; J. D. Windass is a Neuroscience article available to read on EtoBox.
What is Cloning and Functional Characterisation of Two Novel Nicotinic Acetylcholine Receptor α Subunits from the Insect Pest Myzus persicae about?
Abstract: Nicotinic acetylcholine receptors play a major role in excitatory neurotransmission in insect CNSs and constitute an important target for insecticides. Here, we report the isolation and functional characterisation of two cDNAs encoding nicotinic acetylcholine receptor α subunits from a major insect pest, the peach‐potato aphid __Myzus persicae__. These two subunits, termed Mpα1 and Mpα2, are respective structural homologues of the __Drosophila__ Dα2/__Schistocerca gregaria__αL1 α‐subunit pair and the __Drosophila__ ALS α subunit. __Xenopus__ oocyte expression confirmed that each __Myzus__ subunit can form functional acetylcholine‐ or nicotine‐gated channels. However, some electrophysiological and pharmacological properties of the __Myzus__ subunits were distinct from those encoded by the corresponding __Drosophila__ subunits. Coexpression of the __Myzus__ subunits with the chick β2 subunit revealed other differences from the __Drosophila__ system, as only very limited potentiation of agonist‐induced currents was observed with Mpα2 and none with Mpα1. Available data therefore indicate that structurally homologous insect nicotinic acetylcholine receptor α subunits from diff
Who reads Cloning and Functional Characterisation of Two Novel Nicotinic Acetylcholine Receptor α Subunits from the Insect Pest Myzus persicae?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- F. Sgard; S. P. Fraser; M. J. Katkowska; M. B. A. Djamgoz; S. J. Dunbar; J. D. Windass
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 1998
- Language
- EN
- Field
- Neuroscience (Life Sciences)