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What is Thermospray Interface in LC-MS Analysis about?

The thermospray (TSP) interface was developed in 1983 to allow high flow rates of up to 2 ml/min from liquid chromatography columns to be introduced efficiently into a mass spectrometer vacuum system. It worked by passing the liquid chromatography effluent through a heated probe into a desolvation chamber, where the solvent evaporated and ions were produced through direct evaporation or ion-molecule reactions. The TSP interface simplified the mechanical complexity of previous direct liquid introduction inte

Author

AYAZ GUL

Language

EN