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The study investigates the role of layilin as a receptor mediating the induction of tight junction protein ZO-1 by hyaluronan 35 kDa (HA35) in intestinal epithelium. Results show that HA35 treatment enhances ZO-1 expression in mouse intestinal epithelial cells both in vitro and in vivo, and this effect is dependent on layilin rather than other known receptors like TLR-4 or CD44. These findings suggest that HA35 could serve as a dietary supplement to strengthen gut barrier function, particularly in inflammat
- Author
- yshashiprakash25
- Language
- EN