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Patterns of p53 and Ki-67 protein expression in epithelial dysplasia from the floor of the mouth by Kushner, Jennifer; Bradley, Grace; Jordan, Richard C. K. is a Medicine article available to read on EtoBox.

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Oral squamous cell carcinoma develops through a series of precancerous stages manifested at the microscopic level as epithelial dysplasia. Mutation of the p53 tumour suppressor gene is thought to be an important component of oral carcinogenesis. p53 regulates cell proliferation and DNA repair by inhibiting the cell cycle at G1/S; loss of p53 function may therefore lead to aberrant cell kinetics. To date, no studies have examined the relationship between p53 protein and alterations in cell kinetics in oral epithelial dysplasia from a single anatomical site. Serial sections were studied from 40 routinely processed biopsy specimens of epithelial dysplasia from the floor of the mouth. The expression of p53 protein was determined by immunohistochemistry and cell proliferation was studied by immunostaining for the cell cycle-dependent protein Ki-67. The number of positive cells per millimetre of basement membrane was determined using computer image analysis and compared with site-matched normal controls. The mean p53 labelling index (LI) in normal mucosa was low, 3•48 0•92 [mean 95 per cent confidence interval (CI)], and increased sharply in the transition from mild (42•49 21•71) to mode

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Author

Kushner, Jennifer; Bradley, Grace; Jordan, Richard C. K.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1997

Language

EN

Field

Medicine (Health Sciences)