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dGEMRIC (delayed gadolinium-enhanced MRI of cartilage) indicates adaptive capacity of human knee cartilage by Carl Johan Tiderius; Jonas Svensson; Peter Leander; Thorsson Ola; Leif Dahlberg is a Medicine article available to read on EtoBox.
What is dGEMRIC (delayed gadolinium-enhanced MRI of cartilage) indicates adaptive capacity of human knee cartilage about?
## Abstract Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) is a new imaging technique to estimate joint cartilage glycosaminoglycan content by __T__~1~‐relaxation time measurements after penetration of the hydrophilic contrast agent Gd‐DTPA^2‐^. This study compares dGEMRIC in age‐matched healthy volunteers with different levels of physical activity: Group 1 (n = 12): nonexercising individuals; Group 2 (n = 16): individuals with physical exercise averaging twice weekly; Group 3 (n = 9): male elite runners. dGEMRIC was performed 2 hr after an intravenous injection of Gd‐DTPA^2‐^ at 0.3 mmol/kg body weight. __T__~1~ differed significantly between the three different levels of physical exercise. __T__~1~ values (mean of medial and lateral femoral cartilage) for Groups 1, 2, and 3 were: 382 ± 33, 424 ± 22 and 476 ± 36, respectively (ms, mean ± SD) (__P__ = 0.0004, 1 vs. 2 and 0.0002, 2 vs. 3). Irrespective of the exercise level, __T__~1~ was longer in lateral compared to medial femoral cartilage (__P__ = 0.00005; n = 37). In conclusion, this cross‐sectional study indicates that human knee cartilage adapts to exercise by increasing the glycosaminoglycan content. Furthermore, resu
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- Author
- Carl Johan Tiderius; Jonas Svensson; Peter Leander; Thorsson Ola; Leif Dahlberg
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)