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A Novel Electrochemical Sensor Based on Electropolymerized Molecularly Imprinted Poly(aniline-co-anthranilic Acid) for Sensitive Detection of Amlodipine by Hajer Hrichi; Lotfi Monser; Nafaâ Adhoum is a Engineering article available to read on EtoBox.

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A novel voltammetric sensor based on molecularly imprinted poly(aniline-co-anthranilic acid) for determination of amlodipine (AML) was developed. The sensor was prepared by electrocopolymerization of aniline and anthranilic acid in the presence of AML molecules and perchloric acid onto a glassy carbon electrode (GCE) using cyclic voltammetry (CV). Several parameters affecting the performance of the imprinted (MIP) and non-imprinted films (NIP) were optimized. Under optimized operational conditions, the proposed MIP/GCE sensor exhibits two distinct linear responses ranging from 0.01nM to 0.08nM and 0.3nM to 8.0nM respectively with a LOD (3σ/m) of 2.66pM. The precision (RSD, n=6) of the method for intra and inter-days was found to be 0.65% and 1.68% respectively. The selectivity of the MIP/GCE sensor against AML was investigated in the presence of various interfering molecules. The proposed sensor was successfully applied for the detection of AML in pharmaceuticals, human urine, human serum and plasma. The proposed MIP/GCE sensor appeared to be suitable for sensitive and precise quantification of AML in several matrices.

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Author

Hajer Hrichi; Lotfi Monser; Nafaâ Adhoum

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Engineering (Physical Sciences)