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Synthesis, Antimicrobial Activity, Pharmacophore Analysis of Some New 2-(Substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles by Sabiha Alper-Hayta; Mustafa Arisoy; Özlem Temiz-Arpaci; Ilkay Yildiz; Esin Aki; Semiha Özkan; Fatma Kaynak is a Chemistry article available to read on EtoBox.
What is Synthesis, Antimicrobial Activity, Pharmacophore Analysis of Some New 2-(Substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles about?
The synthesis and antimicrobial activity of a new series of 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazole derivatives 3-12 were described. The in vitro antimicrobial activity of the compounds was determined against some Gram-positive, Gram-negative bacteria and fungi and their drug-resistant isolates in comparison with standard drugs. Antimicrobial results indicated that the synthesized compounds possessed a broad spectrum of activity with MIC values 500-15.625 microg/ml. In the series, the most active compound against Candida krusei and Candida albicans isolate is 8 with MIC value 31.25 microg/ml. However, it is one dilution less potent than the compared fluconazole. Some of the screened compounds exhibit significant activity, having MIC value as 31.25 microg/ml in Pseudomonas aeruginosa having same activity as Rifampicin. Furthermore, considering the worth of developing new antibacterial agents against drug-resistant P. aeruginosa the present study explores the structure-activity relationship analysis of 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles using 3D-common features pharmacophore hypotheses approach.
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- Author
- Sabiha Alper-Hayta; Mustafa Arisoy; Özlem Temiz-Arpaci; Ilkay Yildiz; Esin Aki; Semiha Özkan; Fatma Kaynak
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)