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A Randomized Placebo‐controlled Trial of Simethicone and Cisapride for the Treatment of Patients with Functional Dyspepsia by G. Holtmann; J. Gschossmann; P. Mayr; N. J. Talley is a Medicine article available to read on EtoBox.

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## SUMMARY **Aim** : To compare the efficacy of simethicone with placebo and the prokinetic cisapride in patients with functional dyspepsia. **Methods** : One hundred and eighty‐five patients with functional dyspepsia were randomized and treated in a double‐dummy technique with simethicone (105 mg t.d.s.), cisapride (10 mg t.d.s.) or placebo (t.d.s.). The primary outcome measure was the O'Brien global measure of the patients' rating of 10 upper gastrointestinal symptoms (graded as absent=0, moderate=1, severe=2 or very severe=3). Outcome measures were assessed at baseline and after 2, 4 and 8 weeks of treatment (intention‐to‐treat). **Results** : At 2, 4 and 8 weeks, treatment with simethicone and cisapride yielded significantly (all __P__ values < 0.0001) better improvement of symptoms compared to placebo. Simethicone was significantly better than cisapride after 2 weeks (__P__=0.0007), but the differences were not statistically significant after 4 and 8 weeks. Patients treated with simethicone judged the efficacy of their treatment as very good in 46% of cases, compared to 15% and 16% receiving cisapride and placebo, respectively. **Conclusions** : Simethicone and cisapride were

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Author

G. Holtmann; J. Gschossmann; P. Mayr; N. J. Talley

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2002

Language

EN

Field

Medicine (Health Sciences)