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Can I read Drug Holiday Clinical Relevance Verification for Antiresorptive Agents in Medication-related Osteonecrosis Cases of the Jaw on EtoBox?
Drug Holiday Clinical Relevance Verification for Antiresorptive Agents in Medication-related Osteonecrosis Cases of the Jaw by Saki Hayashida; Souichi Yanamoto; Shigeyuki Fujita; Takumi Hasegawa; Takahide Komori; Yuka Kojima; Hironori Miyamoto; Yasuyuki Shibuya; Nobuhiro Ueda; Tadaaki Kirita; Hirokazu Nakahara; Mitsuyo Shinohara; Eiji Kondo; Hiroshi Kurita; Masahiro Umeda is a Medicine article available to read on EtoBox.
What is Drug Holiday Clinical Relevance Verification for Antiresorptive Agents in Medication-related Osteonecrosis Cases of the Jaw about?
Treatment strategies of medication-related osteonecrosis of the jaw (MRONJ) are controversial. Recently, surgical treatment has been reported as superior to nonsurgical treatment, but the contribution discontinued antiresorptive agent use during MRONJ treatment remains unclear. This study aimed to evaluate the efficacy of drug holidays and treatment strategies in MRONJ cases. Four-hundred and twenty-seven patients with MRONJ treated at nine hospitals from 2009 to 2017 were included in this multicenter retrospective study. Multivariate Cox regression analysis showed that the primary disease (osteoporosis or malignant tumor), diabetes, serum albumin, and treatment method (surgical or nonsurgical) were significantly correlated with the cure rate. The cumulative 1-year cure rates in the surgical and nonsurgical treatment groups were 64.7% and 18.2%, respectively. However, discontinuing antiresorptive agents did not influence the treatment outcome in the cohort overall, or in 230 patients after performing propensity score matching among the discontinuation and continuation groups. When stratifying by treatment method, antiresorptive agent discontinuation significantly increased the cure
Who reads Drug Holiday Clinical Relevance Verification for Antiresorptive Agents in Medication-related Osteonecrosis Cases of the Jaw?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Saki Hayashida; Souichi Yanamoto; Shigeyuki Fujita; Takumi Hasegawa; Takahide Komori; Yuka Kojima; Hironori Miyamoto; Yasuyuki Shibuya; Nobuhiro Ueda; Tadaaki Kirita; Hirokazu Nakahara; Mitsuyo Shinohara; Eiji Kondo; Hiroshi Kurita; Masahiro Umeda
- Publisher
- Springer Science and Business Media LLC
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)