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Testing for Hereditary Thrombophilia: a Retrospective Analysis of Testing Referred to a National Laboratory by Brian R Jackson; Kyland Holmes; Amit Phansalkar; George M Rodgers is a Medicine article available to read on EtoBox.

What is Testing for Hereditary Thrombophilia: a Retrospective Analysis of Testing Referred to a National Laboratory about?

## Background Predisposition to venous thrombosis may be assessed through testing for defects and/or deficiencies of a number of hereditary factors. There is potential for confusion about which of these tests are appropriate in which settings. At least one set of recommendations has been published to guide such testing, but it is unclear how widely these have been disseminated. ## Methods We performed a retrospective analysis of laboratory orders and results at a national referral laboratory to gain insight into physicians' ordering practices, specifically comparing them against the ordering practices recommended by a 2002 College of American Pathologists (CAP) consensus conference on thrombophilia testing. Measurements included absolute and relative ordering volumes and positivity rates from approximately 200,000 thrombophilia tests performed from September 2005 through August 2006 at a national reference laboratory. Quality control data were used to estimate the proportion of samples that may have been affected by anticoagulant therapy. A sample of ordering laboratories was surveyed in order to assess potential measurement bias. ## Results Total antigen assays for protein C, prot

Who reads Testing for Hereditary Thrombophilia: a Retrospective Analysis of Testing Referred to a National Laboratory?

Author

Brian R Jackson; Kyland Holmes; Amit Phansalkar; George M Rodgers

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1472-6890)

Published

2008

Language

EN

Field

Medicine (Health Sciences)