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Can I read ACSS2/AMPK/PCNA pathway‑driven proliferation and chemoresistance of esophageal squamous carcinoma cells under nutrient stress on EtoBox?
ACSS2/AMPK/PCNA pathway‑driven proliferation and chemoresistance of esophageal squamous carcinoma cells under nutrient stress by Mi, Lei; Zhou, Yuepeng; Wu, Dan; Tao, Qing; Wang, Xuefeng; Zhu, Haitao; Gao, Xingyu; Wang, Jingzhi; Ling, Rui; Deng, Jing; Mao, Chaoming; Chen, Deyu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is ACSS2/AMPK/PCNA pathway‑driven proliferation and chemoresistance of esophageal squamous carcinoma cells under nutrient stress about?
Although platinum‐based chemotherapy is the first‐line choice for locally advanced or metastatic esophageal squamous cell carcinoma (ESCC) patients, accelerated recurrence and chemoresistance remain inevitable. New evidence suggests that metabolism reprogramming under stress involves independent processes that are executed with a variety of proteins. This study investigated the functions of nutrient stress (NS)‐mediated acetyl‐CoA synthetase short‐chain family member 2 (ACSS2) in cell proliferation and cisplatin‐resistance and examined its combined effects with proliferating cell nuclear antigen (PCNA), a key regulator of DNA replication and repair. Here, it was demonstrated that under NS, when the AMP‐activated protein kinase (AMPK) pathway was activated, ESCC cells maintained proliferation and chemoresistance was distinctly upregulated as determined by CCK‐8 assay. As determined using immunoblotting and RT‐qPCR, compared with normal esophageal epithelial cells (Het‐1A), ESCC cells were less sensitive to NS and showed increased intracellular levels of ACSS2. Moreover, it was shown that ACSS2 inhibition by siRNA not only greatly interfered with proliferation under NS but also parti
Who reads ACSS2/AMPK/PCNA pathway‑driven proliferation and chemoresistance of esophageal squamous carcinoma cells under nutrient stress?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mi, Lei; Zhou, Yuepeng; Wu, Dan; Tao, Qing; Wang, Xuefeng; Zhu, Haitao; Gao, Xingyu; Wang, Jingzhi; Ling, Rui; Deng, Jing; Mao, Chaoming; Chen, Deyu
- Publisher
- Spandidos Publications Ltd; Spandidos Publications (ISSN 1791-2997)
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)