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Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome by Sameh Msaad; Akram Chaabouni; Rim Marrakchi; Mariem Boudaya; Amina Kotti; Walid Feki; Kamel Jamoussi; Samy Kammoun is a Neuroscience article available to read on EtoBox.

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Background. Systemic and airway inflammation has recently been linked to obstructive sleep apnea-hypopnea syndrome (OSAHS) and is considered to be a probable risk factor for OSAHS-induced cardiovascular damage. High-sensitivity C-reactive protein (hs-CRP), as an inflammatory mediator, may be useful for the prediction of the risk of cardiovascular disease (CVD) and assessment of nocturnal continuous positive airway pressure (nCPAP) therapy effect in OSAHS patients. Methods. A prospective, controlled, cross-sectional study was conducted on 64 consecutive adult subjects with suspected sleep-disordered breathing (SDB). Results. OSAHS was confirmed in 43 patients (24 normotensive and 19 hypertensive patients) and ruled out in 21 normotensive subjects (controls). The median plasma level of hs-CRP did not differ significantly between OSAHS patients and controls. It showed an unmarked rise with the severity of OSAHS ( p = 0.20 ) and was not correlated with AHI ( p = 0.067 ; r = 0.28 ). After adjusting for cervical perimeter (CP), waist-to-hip ratio (WHR), and blood sugar level, hs-CRP level of 1 mg/dL or greater was significantly more often observed in OSAHS patients compared with controls

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Author

Sameh Msaad; Akram Chaabouni; Rim Marrakchi; Mariem Boudaya; Amina Kotti; Walid Feki; Kamel Jamoussi; Samy Kammoun

Publisher

Hindawi Limited; London: Hindawi, [2011]- (ISSN 2090-3545)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)