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The influence of calcium ions on the DNA binding behaviour of a new platinum(II) compound linked to an amino phosphonic acid by Th.J. Einhäuser; M. Galanski; E. Vogel; B.K. Keppler is a Chemistry article available to read on EtoBox.

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The binding behaviour towards DNA of the new osteotropic platinum phosphonato complex [c&P~(N&)~(BPMAA)]. 1. (BPMAA = bis( phosphonomethyl)aminoacetic acid), has been investigated. The slow hydrolysiskineticsof I andthelow ~~~~~ in vitro is in contrast to the antitumour activity found in vivo. This strongly suggests an activation mechanism facilitating the form&on ofan adduct with DNA, The fact that a dramatic increase in the binding rate can be observed in the presence of Ca\*' ions and the fact that there is an increased calcium concentration in the region of bone tumours may explain the antitumour activity of 1 against bone tumours.

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Author

Th.J. Einhäuser; M. Galanski; E. Vogel; B.K. Keppler

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0020-1693)

Published

1997

Language

EN

Field

Chemistry (Physical Sciences)