Opening book details…
Can I read The Association Between Antidepressant Use and Hypoglycaemia in Diabetic Patients: a Nested Case–control Study on EtoBox?
The Association Between Antidepressant Use and Hypoglycaemia in Diabetic Patients: a Nested Case–control Study by Hieronymus J. Derijks; Eibert R. Heerdink; Fred H. De Koning; Robert Janknegt; Olaf H. Klungel; Antoine C. Egberts is a Medicine article available to read on EtoBox.
What is The Association Between Antidepressant Use and Hypoglycaemia in Diabetic Patients: a Nested Case–control Study about?
## Abstract ## Purpose Hypoglycaemia is a limiting factor for glycaemic management of diabetes with intensive insulin and/or oral antidiabetic drug (OAD) regimen. Case reports suggest that antidepressants may interfere with blood glucose metabolism in patients with diabetes mellitus potentially increasing the risk of clinically relevant hypoglycaemia. Comorbid depression treated with antidepressants could therefore further complicate glycaemic control. We have carried out a nested case–control study among diabetic patients to assess the risk of hypoglycaemia requiring hospitalisation associated with the use of antidepressants. ## Methods Diabetic patients treated with insulin and/or OADs were selected from the Dutch Pharmo system. Exposure to antidepressants was the primary determinant investigated. Use of antidepressants was further subclassified based on the receptor binding profile to investigate whether specific pharmacological properties could explain a potential influence on glucose homeostasis. Conditional logistic regression was used to estimate odds ratios and to adjust for confounding factors. ## Results From the base cohort (40 600 patients), 549 (1.35%) cases were ident
Who reads The Association Between Antidepressant Use and Hypoglycaemia in Diabetic Patients: a Nested Case–control Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hieronymus J. Derijks; Eibert R. Heerdink; Fred H. De Koning; Robert Janknegt; Olaf H. Klungel; Antoine C. Egberts
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)