Can I read The Role of Mitophagy in the Regulation of Mitochondrial Energetic Status in Neurons on EtoBox?

The Role of Mitophagy in the Regulation of Mitochondrial Energetic Status in Neurons by Sinsuk Han; Mingyang Zhang; Yu Young Jeong; David J. Margolis; Qian Cai is a Medicine article available to read on EtoBox.

What is The Role of Mitophagy in the Regulation of Mitochondrial Energetic Status in Neurons about?

Mitochondria are the main cellular energy powerhouses and supply most of the energy in the form of ATP to fuel essential neuronal functions through oxidative phosphorylation (OXPHOS). In Alzheimer disease (AD), metabolic and mitochondrial disruptions are an early feature preceding any histopathological and clinical manifestations. Mitochondrial malfunction is also linked to synaptic defects in early AD. Mitophagy serves as a key cellular quality control mechanism involving sequestration of damaged mitochondria within autophagosomes and their subsequent degradation in lysosomes. However, it remains largely unknown whether mitophagy is involved in the regulation of energy metabolism in neurons, and if so, whether metabolic deficiency in AD is attributed to mitophagy dysfunction. Here we reveal that mitophagy is broadly activated in metabolically enhanced neurons upon OXPHOS stimulation, which sustains high energetic activity by increasing mitochondrial turnover and hence facilitating mitochondrial maintenance. Unexpectedly, in AD-related mutant HsAPP Tg mouse brains, early stimulation of OXPHOS activity fails to correct energy deficits but exacerbates synapse loss as a consequence of

Who reads The Role of Mitophagy in the Regulation of Mitochondrial Energetic Status in Neurons?

Author

Sinsuk Han; Mingyang Zhang; Yu Young Jeong; David J. Margolis; Qian Cai

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Medicine (Health Sciences)