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Simple Analogs of Acromelic Acid, Which Are Highly Active Agonists of Kainate Type Neuroexcitant by Kimiko Hashimoto; Manabu Horikawa; Haruhisa Shirahama is a Chemistry article available to read on EtoBox.

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The highly stereoselective synthesis of acromelic acid analogs; 3a and 3b, was achieved. The new kainoid 3b was found to be the strongest neuroexcitant among the kainoids known so far. Recently neuropharmacological studies demonstrated that glutamic acid was a putative excitatory neurotransmitter and a glutamate recepter was probably involved in higher brain function such as memory and learnning.' Glutamic acid causes a marked depolarization of mammalian central neurons which lead to specific neuronal death in the brain.\* It plays a key role in ischemic brain damage presumably.3 Neurodegeneration sickness and Huntington's and Alzheimer's diseases, could arise from the abnormal function of the glutamatergic systems.4 The actions of glutamate are mediated by mainly three subtypes of receptors: kainate. quisqualate, and NMDA(N-methyl-D-aspartate) types based on their sensitivities for the above three agonists.5 Thus far, H H HO& acromelic acid A (1) acromelic acid B (2) 3a:R=H

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Author

Kimiko Hashimoto; Manabu Horikawa; Haruhisa Shirahama

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

1990

Language

EN

Field

Chemistry (Physical Sciences)